According to the requirement of safety production in ammunition production line, an anti-sympathetic detonation device of water drop curtain was proposed. APDL is used to program to realize the random throwing of water drops in the water curtain area, and Autodyn simulation software is used to verify the anti-sympathetic detonation effect of the water drop curtain; Through the analysis of 22 working conditions, it is found that with the increase of the number of water droplets in the unit area, the anti-sympathetic detonation effect of the water droplet curtain is enhanced, but when the number of water droplets reaches a certain amount, the attenuation rate of the water droplet curtain on the shock wave overpressure and the fragment velocity tends to be stable. The results show that the attenuation rate of the water drop curtain to the shock wave overpressure is about 63.2%, and the attenuation rate to the fragment velocity is about 87. 5%. The water drop curtain has a good attenuation effect, which ensures the safety and improves the production efficiency.