In order to solve the problems of the traditional methods of missile equipment management, such as tedious work, low efficiency, high error rate and high security risk, an information management scheme of missile equipment based on radio frequency identification (RFID) technology is designed. In the equipment management, electronic lead sealing technology is introduced to explore the solutions of key problems such as frequency selection, coding mode and anti-collision strategy of RFID system. The results show that this method can make the equipment management work more efficient, accurate, safe and reliable, and effectively improve the information level of the army.